SARS-CoV-2 consequences for mental health: Neuroinflammatory pathways linking COVID-19 to anxiety and depression.

The coronavirus disease 2019 (COVID-19) pandemic has been linked to an increased prevalence of mental health disorders, particularly anxiety and depression. Moreover, the COVID-19 pandemic has caused stress in people worldwide due to several factors, including fear of infection; social isolation; difficulty in adapting to new routines; lack of coping methods; high exposure to social media, misinformation, and fake reports; economic impact of the measures implemented to slow the contagion and concerns regarding the disease pathogenesis. COVID-19 patients have elevated levels of pro-inflammatory cytokines, such as interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α, and other inflammation-related factors. Furthermore, invasion of the central nervous system by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may potentially contribute to neuroinflammatory alterations in infected individuals. Neuroinflammation, a consequence of psychological stress due to the COVID-19 pandemic, may also play a role in the development of anxiety and depressive symptoms in the general population. Considering that neuroinflammation plays a significant role in the pathophysiology of depression and anxiety, this study investigated the effects of SARS-CoV-2 on mental health and focused on the impact of the COVID-19 pandemic on the neuroinflammatory pathways.

Swimming in the maze: An overview of maze apparatuses and protocols to assess zebrafish behavior.

Most preclinical behavioral assays use rodents as model animals, leaving room for species-specific biases that could be avoided by an expanded cross-species approach. In this context, zebrafish emerges as an alternative model organism to study neurobiological mechanisms of anxiety, preference, learning, and memory, as well as other phenotypes with relevance to neuropsychiatric disorders. In recent years, several zebrafish studies using different types of mazes have been published. However, the protocols and apparatuses' shapes and dimensions vary widely in the literature. This variation may puzzle researchers attempting to implement maze behavioral assays and challenges the reproducibility across institutions. This review aims to provide an overview of the behavioral paradigms assessed in different types of mazes in zebrafish reported in the last couple of decades. Also, this review aims to contribute to a better characterization of multi-behavioral assessment in zebrafish.